Sentinel ® and Sentinel Spectrum ® is administered by mouth once a month. Sentinel® and Sentinel Spectrum® Directions The way in which praziquantel works against tapeworms is not entirely known, but it is suspected that it interferes with integrity of the worm's skin and causes paralysis. Praziquantel, the third active ingredient in Sentinel Spectrum ®, adds protection against tapeworms. Since lufenuron does not kill adult fleas, it is typically used in combination with other medications to treat active flea infestations. Lufenuron only targets flea eggs and prevents them from developing and hatching. Lufenuron is another active ingredient in Sentinel ® and Sentinel Spectrum ®. By overloading chloride into these worms, it affects the electrical activity within their nervous system, causing muscle paralysis and death. Milbemycin shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, whipworms and hookworms. The main active ingredient in both Sentinel ® and Sentinel Spectrum ® is milbemycin oxime. Sentinel Spectrum ® is intended for dogs and puppies weighing more than two pounds and older than 6 weeks of age. Sentinel Spectrum ®contains the same active ingredients as Sentinel ®, along with the addition of a third ingredient, praziquantel, to provide the additional benefit of preventing and controlling tapeworm infections. It is indicated for adult dogs and puppies weighing more than two pounds and older than 4 weeks of age, for the prevention of heartworm disease, for the prevention and control of flea populations, the control of adult hookworms, and the removal and control of adult roundworms and whipworms. Sentinel® contains two active ingredients, milbemycin oxime and lufenuron. This content shouldn’t take the place of advice by your vet. 5 - Ixodes scapularis & Amblyomma americanum 6 - Dipylidium caninum.PetMD’s medications content was written and reviewed by veterinary professionals to answer your most frequently asked questions about how medications function, their side effects, and what species they are prescribed for. variabilis 3 - Control of tick infestations due to I. felis infestation 2 - Control of tick infestations due to D. multilocularis 1 - Kills adult fleas & prevents flea eggs from hatching for 1 month prevention & control of C. variabilis, Haemaphysalis longicornis x - Adult and L4 A. cati v - Otodectes cynotis w - Control of tick infestations due to I. tubaeforme u - Adult, immature adult, & L4 of T. canis t - Adult, immature adult, & L4 of A. stenocephala q - Adult, immature adult, & fourth-stage larvae (L4) of A. stenocephala adults o - Kills adult fleas prevention & treatment of flea infestations ( C. caninum L4 larvae, immature adults (L5) and adults U. ricinus, Rhipicephalus sanguineus & for 4 weeks against Dermacentor reticulatus n - A. canis) m - Treatment of tick infestations, with immediate & persistent tick killing activity for 5 weeks against Ixodes hexagonus, I. pisiformis i - Adult Ancylostoma tubaeforme j - Prevents development of flea eggs does not kill adult fleas k - Prevention and control of flea populations ( Ctenocephalides felis) l - Treatment of flea infestations ( C. granulosus, Dipylidium caninum g - Adult & immature hookworms (Ancylostoma tubaeforme, A. braziliense) b - Ascarids ( Toxocara canis, Toxascaris leonina) c - Adult Ancylostoma caninum d - Trichuris vulpis e- Toxocara cati f - Taenia pisiformis, Echinococcus multilocularis, E. Revolution® ( Zoetis), Paradyne®( Vethical), Senergy™ ( Virbac), Selarid™ ( Norbrook), Revolt™ ( Aurora)Ī - Ancylostoma caninum, Uncinaria stenocephala, A. ProHeart®6 ( Zoetis), ProHeart®12 ( Zoetis)Īdvantage Multi® ( Elanco), IMOXI™ ( Vetoquinol USA) PARASEDGE TM Multi ( Virbac), Midamox™ ( Norbrook) Injectable Administration (every 6 or 12 months) Moxidectin + sarolaner + pyrantel pamoate Milbemycin oxime + lufenuron + praziquantel Interceptor® ( Elanco), MilbeGuard® ( Ceva) Ivermectin + pyrantel pamoate + praziquantel HEARTGARD® Plus ( Boehringer Ingelheim), Iverhart Plu s® ( Virbac), Tri-Heart® Plus ( Merck) Oral Administration (monthly tablets and chews) Other Parasites Treated in Addition to Heartworm
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